Ethyl 2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetate → 2-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol

HRID 344026Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 344026
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][C:14](OCC)=[O:15].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][CH2:14][OH:15]

Komponenten

4

Edukt 2

HCID 10538520Ethyl 2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 106083702-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanolAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A suspension of ethyl (5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)acetate (1.02 g) and lithium aluminum hydride (0.20 g) in tetrahydrofuran (15 ml was stirred at 0° C. for 2.5 hours. The solution was poured into cold 1N-hydrochlorlc acid, then the resulting mixture was filtered through the celite, and extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo to afford 2-(5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol as a colorless oil (0.85 g).

Aufarbeitung

  1. additionThe solution was poured into cold 1N-hydrochlorlc acid
  2. filtrationthe resulting mixture was filtered through the celite
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b8716bf5d6c94ce5863f698aa20b58da
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05863918

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