HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 344284Erstellt: 26. Oktober 2026
Potassium Carbonate → 1-(3-Ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine
https://huagongshe.com/reaction/344284
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Tert-butyl (piperidin-4-ylmethyl)carbamate | HCID 723429 | — |
| Edukt | 3-Ethylenedioxy-3-(4-methoxyphenyl)propyl bromide | HCID 70073196 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 1-(3-Ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine | HCID 70076348 | 77,2% |
Reaktionsschritte
To a solution of 4-(tert-butoxycarbonylaminomethyl)piperidine (9.70 g) in toluene (160 ml) were added 3-ethylenedioxy-3-(4-methoxyphenyl)propyl bromide (13.0 g) and potassium carbonate (18.8 g), and the resulting mixture was stirred at 80° C. for 16.5 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (chloroform:methanol=20:1) to give 14.7 g of 1-(3-ethylenedioxy-3-(4-methoxyphenyl)propyl)-4-(tert-butoxycarbonylaminomethyl)piperidine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US05864039 |
|---|
| Quelldatensatz | uspto-grants-1999_01 |
|---|
| ORD ID | ord-908e6692c395460fbb5ec4b2619b6875 |
|---|
| Quellennotiz | uspto-grants-1999_01 |
|---|
