2-Thiophenecarboxaldehyde → 4-amino-5-chloro-2-methoxy-N-((1-(5-(2-thienylmethylamino)pentyl)piperidin-4-yl)methyl)benzamide

HRID 344398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 344398
[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1.[S:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[CH:32]=O>>[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][CH2:32][C:28]3[S:27][CH:31]=[CH:30][CH:29]=3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1

Komponenten

3

Edukt 2

HCID 73642-ThiophenecarboxaldehydeHCID 540083634-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Produkt 1

HCID 537599584-amino-5-chloro-2-methoxy-N-((1-(5-(2-thienylmethylamino)pentyl)piperidin-4-yl)methyl)benzamideAusbeute 99,9 %

Versuchsvorschrift

4-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (2 g) as starting compound and 2-thiophenecarboxaldehyde (0.64 g) were reacted and treated in the same manner as in Example 121 to give 2.5 g of 4-amino-5-chloro-2-methoxy-N-((1-(5-(2-thienylmethylamino)pentyl)piperidin-4-yl)methyl)benzamide.

Aufarbeitung

  1. customwere reacted
  2. additiontreated in the same manner as in Example 121

Quellen und Nachweise

ORD-Eintrag
ord-965edb77c7a840769e336d0940f4fb76
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05864039

Notizen zur Reaktion

Wird geladen…