Potassium Carbonate → 4-amino-5-chloro-N-((1-(6-(2,4-difluorophenyl)-6-oxohexyl)piperidin-4-yl)-methyl)-2-methoxybenzamide

HRID 344460

Reaktionsgleichung

Reaktionsgleichung von HRID 344460
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([C:37]1[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=1[F:44])=[O:36]>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][C:38]=3[F:44])=[O:36])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Komponenten

4

Edukt 3

HCID 11430Potassium CarbonateHCID 544758096-Bromo-1-(2,4-difluorophenyl)-1-hexanoneHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Produkt 1

HCID 545419554-amino-5-chloro-N-((1-(6-(2,4-difluorophenyl)-6-oxohexyl)piperidin-4-yl)-methyl)-2-methoxybenzamideAusbeute 40,1 %

Versuchsvorschrift

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.0 g) as starting compound, potassium carbonate (1.5 g) and 6-bromo-1-(2,4-difluorophenyl)-1-hexanone (0.9 g) were reacted and treated in the same manner as in Example 172 to give 0.55 g of 4-amino-5-chloro-N-((1-(6-(2,4-difluorophenyl)-6-oxohexyl)piperidin-4-yl)-methyl)-2-methoxybenzamide.

Aufarbeitung

  1. customwere reacted
  2. additiontreated in the same manner as in Example 172

Quellen und Nachweise

ORD-Eintrag
ord-eef06a3ea6f94158ae857c4f6fa9f12e
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05864039

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