1-(4-Bromobutoxy)naphthalene → 4-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide

HRID 344525

Reaktionsgleichung

Reaktionsgleichung von HRID 344525
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[C:23]1([O:33][CH2:34][CH2:35][CH2:36][CH2:37]Br)[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:37][CH2:36][CH2:35][CH2:34][O:33][C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH:26]=[CH:25][CH:24]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Komponenten

3

Edukt 2

HCID 129582701-(4-Bromobutoxy)naphthaleneHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Produkt 1

HCID 539473004-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Versuchsvorschrift

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 4-(1-naphthyloxy)butyl bromide are reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(4-(1-naphthyloxy)butyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Aufarbeitung

  1. customare reacted
  2. additiontreated in the same manner as in Example 168

Quellen und Nachweise

ORD-Eintrag
ord-8a4f04ca22b84f74bd9ac9328d7c76d4
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05864039

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