1-Eth-1-ynyl-4-(pentyloxy)benzene → 4-(2-(4-Pentoxyphenyl)-ethynyl)-phenyl-sulfur pentafluoride

HRID 344983

Reaktionsgleichung

Reaktionsgleichung von HRID 344983
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([F:13])([F:12])([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH2:14]([O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]#[CH:27])=[CH:22][CH:21]=1)[CH2:15][CH2:16][CH2:17][CH3:18]>C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Pd](Cl)Cl.[Cu](I)I.N1CCCCC1>[CH2:14]([O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]#[C:27][C:2]2[CH:7]=[CH:6][C:5]([S:8]([F:13])([F:12])([F:11])([F:10])[F:9])=[CH:4][CH:3]=2)=[CH:22][CH:21]=1)[CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

6

Edukt 2

HCID 27751191-Eth-1-ynyl-4-(pentyloxy)benzeneHCID 27791941-Bromo-4-(pentafluoro-lambda6-sulfanyl)benzene

Produkt 1

HCID 867451284-(2-(4-Pentoxyphenyl)-ethynyl)-phenyl-sulfur pentafluoride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 83717Copper iodideKatalysatorHCID 13169693Triphenylphosphine palladium dichlorideKatalysatorHCID 8082PiperidineLösungsmittel2×

Versuchsvorschrift

8.5 g of p-bromophenyl-sulfur pentafluoride and 20 ml of piperidine are added to a mixture of 8.5 g of 4-pentoxyphenylacetylene, 20 ml of piperidine, 420 mg of triphenylphosphine-palladium(II) chloride and 30 mg of copper iodide, and the combined mixture is heated for 20 hours. Concentration and working up in the customary manner gives 4-(2-(4-pentoxyphenyl)-ethynyl)-phenyl-sulfur pentafluoride.

Aufarbeitung

  1. temperaturethe combined mixture is heated for 20 hours
  2. concentrationConcentration

Quellen und Nachweise

ORD-Eintrag
ord-d9b160dc297649a4900136f57f6e4fed
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05055223

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