HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1'-Carbonyldiimidazole → 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Edukt | 2,4-Dichloro-5-nitropyridine | HCID 12275765 | — |
| Edukt | N-phenyl-4-hydroxybutylamine | HCID 13755485 | — |
| Edukt | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Produkt | 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one | HCID 19809415 | — |
Reaktionsschritte
Treat 2,4-dichloro-5-nitropyridine with 2-((imidazol-1-yl)methyl)imidazole followed by reaction with N-phenyl-4-hydroxybutylamine, hydrogenation with palladium on carbon and cyclization with carbonyldiimidazole to provide the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05055465 |
| Quelldatensatz | uspto-grants-1991_10 |
| ORD ID | ord-7bcb811284c649ddac8a879a18b7556b |
| Quellennotiz | uspto-grants-1991_10 |