N-Pyridin-4-ylacetamide → HCID 19993658, Verbindung

HRID 345006

Reaktionsgleichung

Reaktionsgleichung von HRID 345006
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:4].[C:19]([NH:22][C:23]1[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=1)(=[O:21])[CH3:20]>C(Cl)(Cl)Cl>[Cl-:1].[C:19]([NH:22][C:23]1[CH:28]=[CH:27][N+:26]([CH2:2][C:3](=[O:4])[NH:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:25][CH:24]=1)(=[O:21])[CH3:20]

Komponenten

4

Edukt 2

HCID 21288N-Pyridin-4-ylacetamideHCID 14819969N-(2-Anilinophenyl)-2-chloroacetamide

Produkt 1

HCID 19993658HCID 19993658, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Dissolved in 30 ml of chloroform are 6.2 g of 2-chloro-N-[2-(phenylamino)phenyl]acetamide and 5.0 g of 4-acetylaminopyridine, and the solution is left on standing overnight. After completion of the reaction, the reaction mixture is held at 5° C. to 10° C., and left on standing at the same temperature for 5 hours. The precipitates, which separate out, are recovered by filtration and recrystallized from ethanol to give the desired compound of 4-acetylamino-1-[2-oxo-2-[[2-(phenylamino)phenyl]amino]ethyl]pyridinium chloride.

Aufarbeitung

  1. waitthe solution is left
  2. customAfter completion of the reaction
  3. customis held at 5° C. to 10° C.
  4. waitleft
  5. waiton standing at the same temperature for 5 hours
  6. customThe precipitates, which separate out
  7. filtrationare recovered by filtration
  8. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8bc1e5a5688149c7b9d2d2d68b2b3456
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05055469

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