Trichloroacetyl chloride → N-(3-chloro)allyl-N-methoxyethyl trichloroacetamide

HRID 34507

Reaktionsgleichung

Reaktionsgleichung von HRID 34507
[Cl:1][CH:2]=[CH:3][CH2:4][NH:5][CH2:6][CH2:7][O:8][CH3:9].C(N(CC)CC)C.[Cl:17][C:18]([Cl:23])([Cl:22])[C:19](Cl)=[O:20]>ClCCl>[Cl:1][CH:2]=[CH:3][CH2:4][N:5]([CH2:6][CH2:7][O:8][CH3:9])[C:19](=[O:20])[C:18]([Cl:23])([Cl:22])[Cl:17]

Komponenten

5

Edukt 3

HCID 6420Trichloroacetyl chlorideHCID 8471TriethylamineHCID 85568957N-(3-chloro)allyl-N-methoxyethylamine

Produkt 1

HCID 54017101N-(3-chloro)allyl-N-methoxyethyl trichloroacetamideAusbeute 92,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

N-(3-chloro)allyl-N-methoxyethylamine (2.25 g, 0.015 mol) and 1.52 g (0.015 mol) triethylamine were stirred in 70 ml dichloromethane. The reaction was kept at approximately 5° C. with an ice-water bath. Trichloroacetyl chloride (2.73 g, 0.015 mol) in 10 ml dichloromethane was added dropwise to the cooled solution. Upon completion of the addition, the mixture was stirred at room temperature for 6 hours. The reaction mixture was then washed twice with saturated brine and dried with sodium sulfate. Rotary evaporation yielded 4.1 g of the above-named product.

Aufarbeitung

  1. customThe reaction was kept at approximately 5° C. with an ice-water bath
  2. additionUpon completion of the addition
  3. washThe reaction mixture was then washed twice with saturated brine
  4. dry with materialdried with sodium sulfate
  5. customRotary evaporation

Quellen und Nachweise

ORD-Eintrag
ord-8acb45df98e14c3a9a8f3a881c597456
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762548

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