Triethylamine → (3-Chloropropanoyl)urea

HRID 345170Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 345170
C1C[NH:6][C:4](=[O:5])[NH:3]C1.C(N(CC)CC)C.[Cl:15][CH2:16][CH2:17][C:18](Cl)=[O:19]>C1(C)C=CC=CC=1>[Cl:15][CH2:16][CH2:17][C:18]([NH:3][C:4]([NH2:6])=[O:5])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 693643-Chloropropionyl chlorideHCID 746152(1H)-Pyrimidinone, tetrahydro-

Produkt 1

HCID 12937417(3-Chloropropanoyl)ureaAusbeute 79,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

20.0 g of N,N'-trimethyleneurea are partially dissolved in 1000 ml of toluene under reflux and admixed with 20.2 g of triethylamine and then dropwise, in the course of 90 minutes, with a solution of 25.4 g of 3-chloropropionyl chloride. Subsequent stirring for 30 minutes, cooling down to 5° C., removal of undissolved matter by filtration and evaporating the filtrate in vacuo gives 24 g of chloropropionylurea of the formula ##STR70## as a beige powder.

Aufarbeitung

  1. temperatureunder reflux
  2. customin the course of 90 minutes
  3. customremoval of undissolved matter
  4. filtrationby filtration
  5. customevaporating the filtrate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e25446250eeb40bdb22986ef2666127e
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05055567

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