Triethylamine → 5-Fluoro-1-methylcarbamoylisatin

HRID 34552

Reaktionsgleichung

Reaktionsgleichung von HRID 34552
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].C(N(CC)CC)C.[CH3:20][N:21]=[C:22]=[O:23]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:22](=[O:23])[NH:21][CH3:20])[C:6](=[O:11])[C:5]2=[O:12]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 2365665-Fluoroisatin

Produkt 1

HCID 142299485-Fluoro-1-methylcarbamoylisatinAusbeute 74,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

Aufarbeitung

  1. temperaturecooling
  2. stirringThe mixture is stirred at room temperature for 30 minutes
  3. filtrationthe precipitates are taken by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c25576f7a14c4b82ae9916dfb75fb8cd
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762839

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