Benzyl Bromide → 1-Phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide

HRID 345854

Reaktionsgleichung

Reaktionsgleichung von HRID 345854
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([Br:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[Br-:24].[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N+:8]=2[CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 7498Benzyl BromideHCID 6099261-Phenyl-3,4-dihydroisoquinoline

Produkt 1

HCID 108096381-Phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The mixture of 1-phenyl-3,4-dihydroisoquinoline (292.0 g) and benzyl bromide (176 ml) in acetonitrile (3 l) was refluxed for 1 hour. After cooling the mixture to room temperature, the solvent was evaporated in vacuo. The residue was triturated with diethyl ether (1 l) to give 1-phenyl-2-benzyl-3,4-dihydroisoquinolinium bromide (471.2 g).

Aufarbeitung

  1. temperaturewas refluxed for 1 hour
  2. customthe solvent was evaporated in vacuo
  3. customThe residue was triturated with diethyl ether (1 l)

Quellen und Nachweise

ORD-Eintrag
ord-d03d24d666134bcbb7e9887a3efdf6d4
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05059608

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