Ethanone, 1-(2,5-dichlorophenyl)- → 2',5'-Dichloro-3-dimethylaminoacrylophenone

Reaktionsgleichung

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH:10]=[CH:14][N:15]([CH3:17])[CH3:16]

Komponenten

Edukt 2

HCID 75587Ethanone, 1-(2,5-dichlorophenyl)-

HCID 78373Dimethylformamide dimethyl acetal

Produkt 1

HCID 28062062',5'-Dichloro-3-dimethylaminoacrylophenone

Versuchsvorschrift

A mixture of 31.0 g of 2',5'-dichloroacetophenone and 25 ml of N,N-dimethylformamide dimethyl acetal is heated on a steam bath for 6 hours, then evaporated to dryness in vacuo. The residue is slurried with hexane, and filtered to give 35.3 g of 2',5'-dichloro-3-dimethylaminoacrylophenone as orange crystals, mp 83°-85° C.

Aufarbeitung

temperatureis heated on a steam bath for 6 hours
customevaporated to dryness in vacuo
filtrationfiltered

Quellen und Nachweise

ORD-Eintrag: ord-8267cf425ada4d1aac246b39c9c5254c
Quelldatensatz: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05059691

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