Dimethylformamide → 1-Piperidinecarboxamide
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1C=CC2N(O)N=NC=2C=1.C[N:18]([CH:20]=[O:21])C>>[N:1]1([C:20]([NH2:18])=[O:21])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Komponenten
4
Versuchsvorschrift
Combine N-(t-butoxycarbonyl)-S-methionine (1.50 g, 6.0 mmol), piperidine (0.51 g, 6.0 mmol) and HOBT (0.91 g, 6.0 mmol) in DMF (40 ml). Add DEC (1.15 g, 6.0 mmol). Stir 5 hours, concentrate in vacuo, and partition between EtOAc and H2O. Wash with aqueous NaHCO3, dry, and concentrate to obtain the piperidine amide as a colorless oil (TLC single spot Rf =0.6 in 5% MeOH/CH2Cl2).
Aufarbeitung
- concentrationconcentrate in vacuo
- custompartition between EtOAc and H2O
- washWash with aqueous NaHCO3
- customdry
- concentrationconcentrate
Quellen und Nachweise
- ORD-Eintrag
- ord-e8f1b928f85f4bde93bc0c0ba5603bd0
- Quelldatensatz
- uspto-grants-1991_10
- Patentnummer
- US05061710
Notizen zur Reaktion
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