Chlorosulfonic acid → 4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]benzene-1-sulfonyl chloride

HRID 346205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 346205
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH2:6]([CH:13]1[S:17][C:16](=[O:18])[NH:15][C:14]1=[O:19])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[S:17]1[CH:13]([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:9][CH:8]=2)[C:14](=[O:19])[NH:15][C:16]1=[O:18]

Komponenten

3

Edukt 2

HCID 24638Chlorosulfonic acidHCID 31570135-Benzyl-1,3-thiazolidine-2,4-dione

Produkt 1

HCID 156164324-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]benzene-1-sulfonyl chloride

Versuchsvorschrift

Chlorosulfonic acid (5 ml) was cooled to 0° C. and the 5-benzyl-2,4-thiazolidinedione prepared above (9.6 mmol, 2.0 g) was added portionwise. The reaction mixture was stirred at room temperature for 0.5 hour and poured into ice (25 g). The solution was extracted with methylene chloride (2×50 ml) and the organic layers were dried (Na2SO4) and solvent removed in vacuo to afford title product which was used without further purification.

Aufarbeitung

  1. additionwas added portionwise
  2. extractionThe solution was extracted with methylene chloride (2×50 ml)
  3. dry with materialthe organic layers were dried (Na2SO4) and solvent
  4. customremoved in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f91e5ce27abd4ecea07d11d7b04d89e3
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05061717

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