HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isopropanol → N4-Phenylquinazoline-4,6-diamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Edukt | 6-Nitro-N-phenylquinazolin-4-amine | HCID 5328189 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Water ethanol | HCID 19096565 | — |
| Produkt | N4-Phenylquinazoline-4,6-diamine | HCID 5328187 | — |
Reaktionsschritte
A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07172749B2 |
| Quelldatensatz | uspto-grants-2007_02 |
| ORD ID | ord-79f0fa1082b04b518e2114cf8bffea1e |
| Quellennotiz | uspto-grants-2007_02 |