Tetrafluoro-m-phenylenediamine dihydrochloride → PD 128483
Reaktionsgleichung
[CH2:1]([N:4]1[CH:13]2[C:8]([C:9]3[N:16]=[C:15]([NH:17]C(=O)C(C)C)[S:14][C:10]=3[CH2:11][CH2:12]2)=[CH:7][CH2:6][CH2:5]1)CC.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[CH3:1][N:4]1[CH:13]2[C:8]([C:9]3[N:16]=[C:15]([NH2:17])[S:14][C:10]=3[CH2:11][CH2:12]2)=[CH:7][CH2:6][CH2:5]1Komponenten
3
Versuchsvorschrift
In a process analogous to Example 16 by substituting (±) N-(4,5,5a,6,7,8-hexahydro-6-methylthiazolo[4,5-f]quinolin-2-yl)-2-methylpropanamide (Example 15) for (±) N-(4,5,5a,6,7,8-hexahydro-6-propylthiazolo[4,5-f]quinolin-2-yl)-2-methylpropanamide (Example 15c), the title compound can be prepared as its dihydrochloride salt, hydrate; mp 265°-267° C. (dec.). [α]D =+164.4° (C=1.17, H2O).
Quellen und Nachweise
- ORD-Eintrag
- ord-11a2341c46d34299aa5811b7d2fe3d60
- Quelldatensatz
- uspto-grants-1988_08
- DOI