Tetrahydrofuran → N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

HRID 346518Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 346518
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14]Cl.C(=O)(O)[O-].[Na+].O1CCCC1>CO>[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 758862-chloro-N,N-dimethylacetamideHCID 143276Methyl[2-(pyridin-4-yl)ethyl]amineHCID 516892Sodium Bicarbonate

Produkt 1

HCID 21081298N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-[2-(methylamino)ethyl]pyridine (34.4 g) and 29.18 g of chloroacetic acid-dimethylamide are dissolved in 200 ml of methanol. After the addition of 20 g of sodium bicarbonate the mixture is refluxed for 5 hours with stirring. For working up the mixture is combined with 1000 ml of tetrahydrofuran, decanted off from the precipitated salts and the solution is filtered through active charcoal. After the limination of the solvent, N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide is obtained as a crude product.

Aufarbeitung

  1. temperatureis refluxed for 5 hours
  2. customdecanted off from the precipitated salts
  3. filtrationthe solution is filtered through active charcoal

Quellen und Nachweise

ORD-Eintrag
ord-8518d2a82ffc4bf1a35ec31a6d3692e5
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173028B2

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