Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate → HCID 15093271, Verbindung

HRID 34672Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34672
[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([O:15]C(C)(C)C)=[O:14])([O:3][CH3:4])=[O:2]>FC(F)(F)C(O)=O>[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([OH:15])=[O:14])([O:3][CH3:4])=[O:2]

Komponenten

3

Edukt 1

HCID 15093267Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate

Produkt 1

HCID 15093271HCID 15093271, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

7.8 g of tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate are stirred in a mixture of 100 ml of trifluoroacetic acid and 100 ml of methylene ohloride at room temperature for 30 min. The solvent is removed in vacuo, and the residue is extracted by stirring with 100 ml of ether/petroleum ether (50°-70° C.) 1/1. After filtration and drying, 6.2 g of melting point 112°-116° C. are obtained, melting point 120°-121° C. after recrystallization from ethyl acetate.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. extractionthe residue is extracted
  3. filtrationAfter filtration
  4. customdrying
  5. custom6.2 g of melting point 112°-116° C. are obtained
  6. custommelting point 120°-121° C. after recrystallization from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e56279be3e36461cb3c5171b1f57e0d3
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762848

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