2-{1-[2-(3-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-2,3-dihydro-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol → 2-{1-[2-(4-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-2,3-dihydro-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

HRID 346843

Reaktionsgleichung

Reaktionsgleichung von HRID 346843
[CH3:1][CH:2]1CC2C(=CC=C(C(O[Si](CC)(CC)CC)(C(F)(F)F)C(F)(F)F)C=2)N1.C(C1C=C(C2OC(C)=C(CCl)N=2)C=CC=1)C.C([C:46]1[CH:47]=[C:48]([C:52]2[O:53][C:54]([CH3:78])=[C:55]([CH2:57][N:58]3[C:66]4[C:61](=[CH:62][C:63]([C:67]([OH:76])([C:72]([F:75])([F:74])[F:73])[C:68]([F:71])([F:70])[F:69])=[CH:64][CH:65]=4)[CH2:60][CH:59]3[CH3:77])[N:56]=2)[CH:49]=[CH:50][CH:51]=1)C>>[CH2:1]([C:51]1[CH:46]=[CH:47][C:48]([C:52]2[O:53][C:54]([CH3:78])=[C:55]([CH2:57][N:58]3[C:66]4[C:61](=[CH:62][C:63]([C:67]([OH:76])([C:68]([F:69])([F:71])[F:70])[C:72]([F:74])([F:75])[F:73])=[CH:64][CH:65]=4)[CH2:60][CH:59]3[CH3:77])[N:56]=2)=[CH:49][CH:50]=1)[CH3:2]

Komponenten

4

Edukt 3

HCID 210822032-{1-[2-(3-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-2,3-dihydro-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-olHCID 210822092-(3-Ethyl-phenyl)-4-chloromethyl-5-methyl-oxazoleHCID 210822122-methyl-5-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-2,3-dihydro-1H-indole

Produkt 1

HCID 115985022-{1-[2-(4-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-2,3-dihydro-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Versuchsvorschrift

In analogy to example 51.3, from 2-methyl-5-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-2,3-dihydro-1H-indole (example 51.2) and 2-(3-ethyl-phenyl)-4-chloromethyl-5-methyl-oxazole was prepared 2-{1-[2-(3-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-2-methyl-2,3-dihydro-1H-indol-5-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol, orange gum, MS: 499 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-84d2811c26f3477181b9d70a5e4cf5ff
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173048B2

Verknüpfte Notizen

Wird geladen…