Potassium Carbonate → 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone

HRID 346984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 346984
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)=[O:19])[CH:16]=3)[N:11]=[C:10]([O:27]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+]>Cl.C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18](=[O:19])[C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([I:26])[CH:21]=4)[CH:16]=3)[NH:11][C:10](=[O:27])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 21082028[4-(3-Chlorophenyl)-2-methoxy-6-quinolinyl](3-iodophenyl)-methanone

Produkt 1

HCID 210820354-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinoneAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of intermediate (73) (0.0304 mol) in HCl 3N (150 ml) and THF (70 ml) was stirred and refluxed overnight, brought to room temperature, poured out into ice water and basified with potassium carbonate. The precipitate was filtered, washed with 2-propanone and dried, yielding 13 g (88%) of 4-(3-chlorophenyl)-6-(3-iodobenzoyl)-2(1H)-quinolinone (intermediate 74).

Aufarbeitung

  1. temperaturerefluxed overnight
  2. custombrought to room temperature
  3. filtrationThe precipitate was filtered
  4. washwashed with 2-propanone
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-df125b2042124c39917f6eb35422eafd
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173040B2

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