Reaktionsgleichung
CCCCCC.[C:7]([C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)(=[O:9])[CH3:8].C(OCC)(=[O:17])C>>[S:12]1[CH:13]=[CH:14][C:10]([C:7]([CH:8]=[O:17])=[O:9])=[CH:11]1Komponenten
Versuchsvorschrift
3-Acetylthiophene (20.0 g., 0.159 mol) and SeO2 (19.4 g., 0.175 mol) were dissolved 100 ml. dioxane and 8 ml. H2O by warming to 35°, then heated at reflux 16 hours. The reaction mixture was cooled, filtered and the filtrate stripped to a sludge (the hydrate of title product in crude form). The latter was distilled at reduced pressure to yield title product contaminated with about 10% starting material, 8.53 g.; tlc (5:3 hexane:ethyl acetate) Rf 0.27 (title product) and 0.59 (3-acetylthiophene). The latter was chromatographed on silica gel with 5:3 hexane:ethyl acetate is eluant. Clean product fractions were combined stripped to a solid, triturated with hexane, filtered and the solids (5.60 g.) sublimed to yield purified title product, 3.20 g.; tlc Rf 0.27 as above; sublimation point 70°/1 mm; ms: parent 141, base 111.
Quellen und Nachweise
- ORD-Eintrag
- ord-e5c3e644d2c14d5fa80856e7171e0116
- Quelldatensatz
- uspto-grants-1988_08
- Patentnummer
- US04762921
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