2-Octylcyclopropane-1-carbonyl chloride → HCID 178442566, Verbindung

HRID 34749

Reaktionsgleichung

Reaktionsgleichung von HRID 34749
[NH:1]([CH2:5][CH2:6][CH2:7][CH2:8][NH2:9])[C:2]([NH2:4])=[NH:3].[CH2:10]([CH:18]1[CH2:20][CH:19]1[C:21](Cl)=[O:22])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]>N1C=CC=CC=1>[CH2:10]([CH:18]1[CH2:20][CH:19]1[C:21]([NH:9][CH2:8][CH2:7][CH2:6][CH2:5][NH:1][C:2]([NH2:4])=[NH:3])=[O:22])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Komponenten

4

Edukt 2

HCID 212989522-Octylcyclopropane-1-carbonyl chlorideHCID 178512945HCID 178512945, Verbindung

Produkt 1

HCID 178442566HCID 178442566, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To 457.2 mg. of 1-amino-4-guanidinobutane (IV) suspended in 60 ml. of dry pyridine was added 2-(n-octyl)cyclopropanecarbonyl chloride. This suspension was stirred at room temperature for 40 hours. At the end of 40 hours the solid material was filtered and the filtrate concentrated to a viscous oil, which was chromatographed on silica gel using 30% methanol in CHCl3, resulting in 497.7 mg. of desired material, characterised by EIMS with M+ at m/e 310 for C17H34 -N4O.

Aufarbeitung

  1. filtrationAt the end of 40 hours the solid material was filtered
  2. concentrationthe filtrate concentrated to a viscous oil, which
  3. customwas chromatographed on silica gel using 30% methanol in CHCl3
  4. customresulting in 497.7 mg

Quellen und Nachweise

ORD-Eintrag
ord-8c0559e8a9bc4f13af064a7b25466c52
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762949

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