HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Edukt | 4-Amino-2-(4-phthalimidobutyl)pyrimidine | HCID 20450337 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine | HCID 54214531 | 69,8% |
Reaktionsschritte
A mixture of 4-amino-2-(4-phthalimidobutyl)pyrimidine (1 g.), 2,2,2-trifluoroethylisothiocyanate (1 g.) and acetonitrile was stirred at 70° for 18 hours. The mixture was diluted with acetonitrile (10 ml.), cooled in ice and then filtered to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine (1.03 g.), m.p. 204°-205°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04762932 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-ca82245d01c64c8aa746d59c200086f1 |
| Quellennotiz | uspto-grants-1988_08 |