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HRID 347697Erstellt: 23. Oktober 2026

Sodium Carbonate → 2-[4-(3-Trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)pyridin-2-yl]-benzonitrile

https://huagongshe.com/de/reaction/347697

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktSodium CarbonateHCID 10340—
Edukt2-(2-Cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 3570229—
Edukt7-(2-Chloropyridin-4-yl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazineHCID 11335561—
KatalysatorHCID 178418397HCID 178418397—
Lösungsmittel1,2-DimethoxyethaneHCID 8071—
Produkt2-[4-(3-Trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)pyridin-2-yl]-benzonitrileHCID 99071724%

Reaktionsschritte

7-(2-Chloropyridin-4-yl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine was coupled with 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile in the presence of tetrakis(triphenylphosphine)palladium(0) and sodium carbonate, at 80° C. in aqueous 1,2-dimethoxyethane, to give the title compound in 4% yield: 1H NMR (360 MHz, CDCl3) δ 7.60 (1H, td, J 1.1, 7.7), 7.78 (1H, td, J 1.1, 7.7), 7.89 (1H, dd, J 1.1, 7.7), 7.97 (1H, dd, J 7.0, 0.7), 8.13 (1H, dd, J 1.8, 5.3), 8.65 (1H, d, J 0.7), 8.84 (1H, s), 8.94 (1H, s), 8.99 (1H, dd, J 0.7, 5.3).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07176203B2
Quelldatensatzuspto-grants-2007_02
ORD IDord-a85ff706bf0648e6ab9541b1056b7af9
Quellennotizuspto-grants-2007_02