2-Chloro-4-(2-fluoro-5-methylanilino)pyrimidine → HCID 21083734, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:3]=1[NH:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7](Cl)[N:6]=1.[CH3:17][N:18]([CH2:20][CH:21]([OH:32])[CH2:22][N:23]([C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=1)[CH3:24])[CH3:19]>>[CH3:19][N:18]([CH2:20][CH:21]([OH:32])[CH2:22][N:23]([C:25]1[CH:26]=[CH:27][C:28]([NH:29][C:7]2[N:6]=[C:5]([NH:4][C:3]3[CH:12]=[C:13]([CH3:16])[CH:14]=[CH:15][C:2]=3[F:1])[CH:10]=[CH:9][N:8]=2)=[CH:30][CH:31]=1)[CH3:24])[CH3:17]Komponenten
3
Versuchsvorschrift
By a procedure analogous to Example 96, 4-(2-fluoro-5-methylanilino)-2-chloropyrimidine (Reference Example A-10) and 4-[3-(N,N-dimethyl)amino-2-hydroxypropyl(N-methyl)amino]aniline (Reference Example D-2) were reacted to give the title product as a brown oil (60 mg, 17%). M/z: (ES+) 425.3 (MH+). HPLC (Hypersil 10 cm base deactivated) 60% MeCN/H2O/0.2% TFA. Retention time: 2.66 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-6b34e72de2ce419b8f68d8eeddab1dc4