Methylamine → HCID 178485047, Verbindung

HRID 34780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34780
[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[N:22][C:23]#[N:24])SC)[N:8]=1.[CH3:28][NH2:29]>C(O)C>[F:1][C:2]([F:27])([F:26])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19]([NH:29][CH3:28])=[N:22][C:23]#[N:24])[N:8]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 178503915HCID 178503915, Verbindung

Produkt 1

HCID 178485047HCID 178485047, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(3-cyano-2-methylisothioureido)butylthio]pyrimidine (0.17 g.) in 33% w/v methylamine in ethanol was left at room temperature for 18 hours and then evaporated to dryness. The residue was triturated with ether and the insoluble solid collected and recrystallised from ethyl acetate to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[4-(2-cyano-3-methylguanidino)butylthio]pyrimidine, m.p. 179°-180°.

Aufarbeitung

  1. customevaporated to dryness
  2. customThe residue was triturated with ether
  3. customthe insoluble solid collected
  4. customrecrystallised from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-fc1d596c752c4b029af49257fbc274b8
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762932

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