Ammonia → Oxane-4-carboxamide

Concentrated aqueous ammonia (50 mL) was added to methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) and the reaction mixture was stirred for 43.5 hours at room temperature. The reaction mixture was then cooled in an ice water bath, after which the precipitate was filtered out and dried under reduced pressure at 40° C. to afford 33.4 g of the title compound (74.6% yield).

1. temperatureThe reaction mixture was then cooled in an ice water bath
2. filtrationafter which the precipitate was filtered out
3. customdried under reduced pressure at 40° C.

ORD-Eintrag

ord-252e002dbf1d499fbd2f04606d198237

Quelldatensatz

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07176216B2