HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Methylthio)pyrimidin-4-amine → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Methylthio)pyrimidin-4-amine | HCID 259225 | — |
| Edukt | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine | HCID 54247278 | 51,2% |
Reaktionsschritte
A mixture of 4-amino-2-methylthiopyrimidine (2.1 g.), 2,2,2-trifluoroethylisothiocyanate (2.8 g.) and acetonitrile (5 ml.) was stirred at 70° for 72 hours and then cooled, and the solid that crystallised was collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-methylthiopyrimidine (2.15 g.) which was used without further purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04762932 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-7d02c212b0174ca7822449c59ef637eb |
| Quellennotiz | uspto-grants-1988_08 |