Triethylamine → (2R)-Butan-2-YL methanesulfonate

HRID 348419

Reaktionsgleichung

Reaktionsgleichung von HRID 348419
[CH3:1][S:2]([O:5]S(C)(=O)=O)(=[O:4])=[O:3].[CH3:10][C@@H:11](O)[CH2:12][CH3:13].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:5][C@H:11]([CH3:10])[CH2:12][CH3:13])(=[O:4])=[O:3]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 81560Methanesulfonic anhydrideHCID 84682(-)-2-Butanol

Produkt 1

HCID 148500(2R)-Butan-2-YL methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of methanesulphonic anhydride (8.33 g, 47.8 mmol) in dichloromethane (30 ml) was added dropwise over 30 minutes to an ice-cooled solution of (R)-2-butanol (4.0 ml, 43.5 mmol) and triethylamine (6.65 ml, 47.8 mmol) in dichloromethane (70 ml). The reaction was then allowed to warm to room temperature and stirred for 18 hours. The mixture was then washed with water, 2N hydrochloric acid, then dried (Na2SO4) and evaporated under reduced pressure to give the title compound as a pale yellow oil, 7.0 g.

Aufarbeitung

  1. washThe mixture was then washed with water, 2N hydrochloric acid
  2. dry with materialdried (Na2SO4)
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-90301e4243ad4986aac61da05fd1e19a
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176311B2

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