HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol | HCID 2774691 | — |
| Edukt | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| Produkt | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester | HCID 69523459 | 28% |
Reaktionsschritte
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-ol (32 mg, 0.17 mmol) as the source alcohol. Chromatographic (30–40% ethyl acetate/hexane) purification yielded 22 mg (28%) of the titled compound. ESI-MS t/z 462 (MH+), 460 (M−H−).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07176310B1 |
| Quelldatensatz | uspto-grants-2007_02 |
| ORD ID | ord-6bf752b0309a4bf8a2d5128e0253f2b9 |
| Quellennotiz | uspto-grants-2007_02 |