Hydrochloric Acid → tert-Butyl propiolate
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:33])NC(CC1C=C(F)C=C(F)C=1)C(O)CNC1(C2C=CC=C(C#C)C=2)CC1)([CH3:4])([CH3:3])[CH3:2].Cl.O1CCO[CH2:37][CH2:36]1>CO>[C:6]([C:36]#[CH:37])([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:33]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester (2.34 g, 5.13 mmol) was treated with 4N HCl in dioxane (15.8 mL, 63.3 mmol). The resulting heterogeneous mixture was treated with methanol (10 mL) whereupon it became homogeneous over 30 min. The volatiles were evaporated in vacuo. Dioxane (20 mL) was added and the mixture was evaporated in vacuo to produce a white solid (2.33 g, 106%).
Aufarbeitung
- customThe volatiles were evaporated in vacuo
- additionDioxane (20 mL) was added
- customthe mixture was evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-cd9b0323cdc74c188f142cd7af870c28
- Quelldatensatz
- uspto-grants-2007_02
- Patentnummer
- US07176242B2
Notizen zur Reaktion
Wird geladen…