2-(3-Oxocyclohexyl)acetic acid → N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide
Reaktionsgleichung
O=C1CCCC(CC(O)=O)C1.[F:12][C:13]1[CH:14]=[C:15]([CH:45]=[C:46]([F:48])[CH:47]=1)[CH2:16][C@H:17]([NH:31][C:32](=[O:44])[CH2:33][CH:34]1[CH2:39][CH2:38][CH:37](CCC)[C:36](=[O:43])[CH2:35]1)[C@H:18]([OH:30])[CH2:19][NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][CH3:29])[CH:23]=1>>[F:12][C:13]1[CH:14]=[C:15]([CH:45]=[C:46]([F:48])[CH:47]=1)[CH2:16][C@H:17]([NH:31][C:32](=[O:44])[CH2:33][CH:34]1[CH2:39][CH2:38][CH2:37][C:36](=[O:43])[CH2:35]1)[C@H:18]([OH:30])[CH2:19][NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][CH3:29])[CH:23]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
Step 3 N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxocyclohexyl)acetamide was prepared in 23% yield from (3-Oxo-cyclohexyl)-acetic acid by the method described for the synthesis of N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-2-(3-oxo-4-propylcyclohexyl)acetamide (EXAMPLE SP-297.)