Hydrochloric Acid → N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride

HRID 34938Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34938
[O:1]([C:8]1[C:9]([C:14]([NH:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.[ClH:34]>>[ClH:34].[NH2:19][CH2:18][CH2:17][NH:16][C:14]([C:9]1[C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:15]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 13800228t-Butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate

Produkt 1

HCID 13800260N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride

Versuchsvorschrift

8.7 g of t-butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 3, paragraph 2. The residue was converted into the hydrochloride which was recrystallized twice from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride as white crystals, m.p. 180°-186°.

Aufarbeitung

  1. customwas recrystallized twice from ethanol/ether

Quellen und Nachweise

ORD-Eintrag
ord-64f995007abf4ea6972aba508349a44e
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04764522

Notizen zur Reaktion

Wird geladen…