HCID 22139808, Verbindung → methyl 3-amino-4-chlorothiophene-2-carboxylate
Reaktionsgleichung
C([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12])(=O)C>CO.Cl>[NH2:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
was obtained by stirring a solution of 7 g of methyl 3-acetylamino-4-chlorothiophene-2-carboxylate in a mixture of 50 ml of methanol and 50 ml of concentrated hydrochloric acid at 60° C. for 4 hours and at room temperature for 2 days. The mixture was filtered, the solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water were added and the crystals were filtered off after stirring at room temperature. Crystalline product. M.p. 62–64° C.
Aufarbeitung
- customwas obtained
- filtrationThe mixture was filtered
- distillationthe solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water
- additionwere added
- filtrationthe crystals were filtered off
Quellen und Nachweise
- ORD-Eintrag
- ord-7f266a2370f04a3e9cd7fc83367554db
- Quelldatensatz
- uspto-grants-2007_02
- Patentnummer
- US07179830B2
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