Cesium carbonate → {4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

HRID 349455

Reaktionsgleichung

Reaktionsgleichung von HRID 349455
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[N:10][NH:11][N:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:13](=O)([O-])[O-].[Cs+].[Cs+].[CH3:19][O:20][P:21]([CH:25](C)[C:26]1[CH:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=1)(=[O:24])[O:22][CH3:23]>CN(C=O)C.C(OCC)(=O)C>[CH3:23][O:22][P:21]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:13][N:10]2[N:11]=[N:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)=[N:9]2)=[CH:30][CH:31]=1)(=[O:24])[O:20][CH3:19]

Komponenten

6

Edukt 3

HCID 10796Cesium carbonateHCID 40730565-(3-bromophenyl)-1H-1,2,3,4-tetrazoleHCID 86626606HCID 86626606, Verbindung

Produkt 1

HCID 86626605{4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 5-(3-bromophenyl)-2H-tetrazole (0.5 g, 2.22 mmol) in DMF (15 mL) was added cesium carbonate (0.94 g, 2.89) and the mixture stirred at room temperature for 15 minutes. To this was added (4-bromo-methylbenzyl) phosphonic acid dimethyl ester (0.85 g, 3.05 mmol) and the reaction mixture stirred over night at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water, brine, dried over MgSO4, filtered, and the evaporated to dryness.

Aufarbeitung

  1. stirringthe reaction mixture stirred over night at room temperature
  2. washwashed with water, brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c479c7576f7a455e905f468b16856b1b
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179822B2

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