N-(2-aminoethyl)acetamide → N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

HRID 34946

Reaktionsgleichung

Reaktionsgleichung von HRID 34946
[Br:1][C:2]1[O:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[C:10]([NH:13][CH2:14][CH2:15][NH2:16])(=[O:12])[CH3:11]>C(Cl)Cl.C(N(CC)CC)C>[NH:13]([CH2:14][CH2:15][NH:16][C:7]([C:5]1[O:6][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:8])[C:10]([CH3:11])=[O:12]

Komponenten

5

Edukt 2

HCID 66082N-(2-aminoethyl)acetamideHCID 27570115-Bromofuran-2-carbonyl chloride

Produkt 1

HCID 13800218N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittel2×HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

A solution of 22.6 g of 5-bromo-2-furancarboxylic acid chloride in 100 ml of methylene chloride was added dropwise within 20 minutes at 0°-8° to a solution, pre-cooled to 0°, of 11.0 g of monoacetyl-ethylenediamine in 250 ml of methylene chloride and 18 ml of triethylamine. The reaction mixture was stirred at room temperature overnight, suction filtered and washed with methylene chloride. There was obtained N-(2-acetamino ethyl)-5-bromo-2-furancarboxamide as pale beige crystals, m.p. 175°-176°.

Aufarbeitung

  1. filtrationsuction filtered
  2. washwashed with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-06adfa65536a4672ba2c77c29a74e2ea
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04764522

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