Picolinic acid → Pyridine-2-carbonyl chloride

HRID 34949

Reaktionsgleichung

Reaktionsgleichung von HRID 34949
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1.CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:12])=[O:9]

Komponenten

5

Edukt 2

HCID 1018Picolinic acidHCID 24386Thionyl Chloride

Produkt 1

HCID 135034Pyridine-2-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.

Aufarbeitung

  1. temperaturethe suspension was heated
  2. customThereafter, the mixture was evaporated to dryness under reduced pressure
  3. additionthe residue was treated with toluene
  4. customagain evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0c9b8f17431e45df938f2c9f0e1931bb
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04764522

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