Ethyl formate → 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

HRID 349571Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 349571
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.[CH:12](OCC)=[O:13]>>[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH:11][CH:12]=[O:13])[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 8025Ethyl formateHCID 1357327622-(2,3-Dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethanamine

Produkt 1

HCID 1363341052-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

Versuchsvorschrift

A suspension of 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine (155 mg) in ethyl formate (3 ml) was refluxed for 4.5 hours. After evaporation of the solvent in vacuo, the residue was triturated with ethyl acetate and dried in vacuo to give 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (165 mg) as a solid.

Aufarbeitung

  1. temperaturewas refluxed for 4.5 hours
  2. customAfter evaporation of the solvent in vacuo
  3. customthe residue was triturated with ethyl acetate
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-20db1619b3a544cd8dc99178597891e5
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179801B2

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