Chlorosulfonic acid → 4-methoxy-2-morpholin-4-yl-benzenesulfonic Acid
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:4]=1.Cl[S:16]([OH:19])(=[O:18])=[O:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:16]([OH:19])(=[O:18])=[O:17])=[C:5]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:4]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
To a cooled (0° C.), stirred portion of 1-methoxy-3-morpholin-4-yl-benzene (1.08 g; 5.6 mmol) was added neat to chlorosulfonic acid (1.8 mL; 28 mmol) via pipette over 2 minutes under calcium sulfate-dried atmosphere. The resulting thick, red solution was allowed to warm to room temperature and stirred for 5 hours. The resulting solution was poured onto ice, then extracted with CH2Cl2 (3×50 mL). Combined organic layers then were washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the acid as a light green solid (0.31 g; 20%).