2-Methoxy-5-nitroaniline → HCID 11668152, Verbindung

HRID 349729

Reaktionsgleichung

Reaktionsgleichung von HRID 349729
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:4]=1[NH2:5].[Cl:13][C:14]1[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:15]=1[C:16]([N:18]=[C:19]=[O:20])=[O:17]>CN1CCCC1=O>[Cl:13][C:14]1[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:15]=1[C:16]([NH:18][C:19]([NH:5][C:4]1[CH:6]=[C:7]([N+:10]([O-:12])=[O:11])[CH:8]=[CH:9][C:3]=1[O:2][CH3:1])=[O:20])=[O:17]

Komponenten

4

Edukt 2

HCID 74472-Methoxy-5-nitroanilineHCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Produkt 1

HCID 11668152HCID 11668152, VerbindungAusbeute 96,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

1 g (5.9 mmol) of 2-methoxy-5-nitroaniline were admixed with 1.3 g (5.9 mmol) of 2-chloro-4,5-difluorobenzoyl isocyanate from stage a in 2 ml of N-methylpyrrolidone and reacted at room temperature for one hour. The precipitate was filtered off, washed twice with 5 ml of acetonitrile each time and dried under high vacuum. 2.2 g of the desired product were obtained which were used in stage c without further purification.

Aufarbeitung

  1. customreacted at room temperature for one hour
  2. filtrationThe precipitate was filtered off
  3. washwashed twice with 5 ml of acetonitrile each time
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-3f8c8a6abb5a41e6a0cce92ad6ed6b7d
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179941B2

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