HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Atropic acid → 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Atropic acid | HCID 68114 | — |
| Edukt | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid | HCID 45588421 | 54,3% |
Reaktionsschritte
Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07179922B2 |
| Quelldatensatz | uspto-grants-2007_02 |
| ORD ID | ord-908250ec0eec43b19824e226329ee85a |
| Quellennotiz | uspto-grants-2007_02 |