HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → Codeine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Morphine | HCID 5288826 | — |
| Katalysator | Phenyltrimethylammonium chloride | HCID 67309 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | Codeine | HCID 5284371 | 97,6% |
Reaktionsschritte
Morphine of 82.5% purity, 235 parts (1 mole parts), potassium carbonate 276 parts (2 moles part) and trimethylphenyl-ammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene at 45°-110° C. for 4-8 hrs. to yield 292 parts of codeine (97.6% yield) after workup as in Example 1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04764615 |
| Quelldatensatz | uspto-grants-1988_08 |
| ORD ID | ord-816e9d326d0d450a8485433006b3074c |
| Quellennotiz | uspto-grants-1988_08 |