Hydrochloric Acid → 2-(1-Benzyl-5-phenyl-1H-pyrazol-4-YL)acetic acid

HRID 349929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 349929
[CH2:1]([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11](CC#N)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:22].[K+].Cl.[CH2:25]([OH:27])[CH3:26]>>[CH2:1]([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]([CH2:26][C:25]([OH:22])=[O:27])[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 23024861(1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetonitrile

Produkt 1

HCID 230247242-(1-Benzyl-5-phenyl-1H-pyrazol-4-YL)acetic acidAusbeute 99 %

Versuchsvorschrift

A mixture of (1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetonitrile (3.50 g), a 4N aqueous potassium hydroxide solution (16 ml), and ethanol (50 ml) was refluxed for 4 hours. The reaction mixture was acidified with 1N hydrochloric acid, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated to obtain (1-benzyl-5-phenyl-1H-pyrazol-4-yl)acetic acid (3.70 g, yield: 99%) as a colorless oily substance.

Aufarbeitung

  1. extractionwas extracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with saturated aqueous sodium chloride solution
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a9d90f6648744fa5a87a01702b35a9bc
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179823B1

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