ethyl 1-(4-phenoxybenzyl)-3-(4-phenoxybenzyloxy)-1H-pyrazole-4-carboxylate → HCID 178469747, Verbindung

HRID 349993

Reaktionsgleichung

Reaktionsgleichung von HRID 349993
[O:1]([C:8]1[CH:39]=[CH:38][C:11]([CH2:12][N:13]2[CH:17]=[C:16]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:15]([O:23]CC3C=CC(OC4C=CC=CC=4)=CC=3)=[N:14]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[C].[Pd].O1CCCC1>[OH:23][C:15]1[C:16]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:17][N:13]([CH2:12][C:11]2[CH:38]=[CH:39][C:8]([O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:9][CH:10]=2)[N:14]=1

Komponenten

4

Edukt 1

HCID 23024849ethyl 1-(4-phenoxybenzyl)-3-(4-phenoxybenzyloxy)-1H-pyrazole-4-carboxylate

Produkt 1

HCID 178469747HCID 178469747, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of ethyl 1-(4-phenoxybenzyl)-3-(4-phenoxybenzyloxy)-1H-pyrazole-4-carboxylate (21.50 g), 5% palladium-carbon (10.43 g) and tetrahydrofuran (300 ml) was stirred overnight under a hydrogen atmosphere. After the palladium-carbon was removed by filtration, the filtrate was concentrated to obtain ethyl 3-hydroxy-1-(4-phenoxybenzyl)-1H-pyrazole-4-carboxylate (13.35 g, yield 96%) as colorless crystals. This was recrystallized from acetone-hexane. Melting point: 117–118° C.

Aufarbeitung

  1. customAfter the palladium-carbon was removed by filtration
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-46f70ba9ab664e74ae39e55302a2eab0
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179823B1

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