Piperidine → Methyl 3-(piperidin-1-ylmethyl)benzoate

Beteiligte Stoffe

Reaktionsschritte

A mixture of piperidine (25 ml) and 3-(bromomethyl)benzoic acid, methyl ester (20 g) in toluene (600 ml) was stirred at room temperature for 4 h. The white preciptiate was removed by filtration and the filtrate was distilled to give the title compound as a colourless oil (17.56 g) b.p. 110° (10-1 mm). TLC silica; ether; Rf 0.7.

Herkunft & Nachweise