Hydrochloric Acid → 3-Hydroxy-4-methoxypicolinic acid hydrochloride

HRID 350652

Reaktionsgleichung

Reaktionsgleichung von HRID 350652
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[ClH:20]>CO>[ClH:20].[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 199602893-Benzyloxy-4-methoxypicolinic acid

Produkt 1

HCID 694976023-Hydroxy-4-methoxypicolinic acid hydrochlorideAusbeute 54,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Benzyloxy-4-methoxypicolinic acid (8.3 g) was dissolved in 100 ml of methanol. Concentrated hydrochloric acid (2 ml) was added to the solution. The mixture was heated under reflux for 30 min. The reaction solution was concentrated under the reduced pressure. The residue was recrystallized from water-ethanol to give 3.6 g (yield 54.8%) of title compound as colorless powder.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 min
  3. concentrationThe reaction solution was concentrated under the reduced pressure
  4. customThe residue was recrystallized from water-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a78ece4b9afc480db0193fba1d565803
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183278B1

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