Potassium Carbonate → 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

HRID 350957

Reaktionsgleichung

Reaktionsgleichung von HRID 350957
[CH3:1][NH:2][CH:3]([CH3:5])[CH3:4].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH:3]([N:2]([CH2:13][C:11]1[N:12]=[C:8]([NH2:7])[S:9][CH:10]=1)[CH3:1])([CH3:5])[CH3:4]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)HCID 78485N-Methylisopropylamine

Produkt 1

HCID 210906044-((Isopropyl(methyl)amino)methyl)thiazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

N-methyl-N-isopropylamine (3.02 g, 41 mmol) is added to a suspension of 2-amino-4-chloromethylthiazole hydrochloride (0.185 g, 1.0 mmol) in 15 mL ethanol. The reaction mixture is allowed to stand at room temperature for 4 days. The mixture was poured into aqueous potassium carbonate. The resulting aqueous suspension is extracted with dichloromethane. The organic layer is dried over MgSO4 and condensed to brown oil.

Aufarbeitung

  1. extractionThe resulting aqueous suspension is extracted with dichloromethane
  2. dry with materialThe organic layer is dried over MgSO4 and condensed to brown oil

Quellen und Nachweise

ORD-Eintrag
ord-c3743e0ec4dd42899e707ab5c78cd1e5
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183300B2

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