Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetate → (R)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid methyl ester

HRID 350988

Reaktionsgleichung

Reaktionsgleichung von HRID 350988
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[N:19]=[CH:18][C:17]([F:20])=[CH:16][C:12]=3[C:13]([OH:15])=O)=[CH:9][C:4]=2[O:3][CH2:2]1.[CH3:21][O:22][C:23](=[O:36])[C@H:24]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][NH2:34])=[C:29]([F:35])[CH:28]=1)[CH3:25].COC(=O)COC1C=CC(CN)=C(F)C=1>>[CH3:21][O:22][C:23](=[O:36])[C@H:24]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][NH:34][C:13]([C:12]2[C:11]([O:10][C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)=[N:19][CH:18]=[C:17]([F:20])[CH:16]=2)=[O:15])=[C:29]([F:35])[CH:28]=1)[CH3:25]

Komponenten

4

Edukt 3

HCID 18174008Methyl 2-[4-(aminomethyl)-3-fluorophenoxy]acetateHCID 220584122-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-nicotinic acidHCID 60128049(R)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid methyl ester

Produkt 1

HCID 60128054(R)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-5-fluoro-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid methyl ester

Versuchsvorschrift

The compound of Formula (5.0.32) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(benzo[1,3]dioxol-5-yloxy)-5-fluoro-nicotinic acid and (R)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid methyl ester for the corresponding 2-(benzo-[[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

Aufarbeitung

  1. customthat described in Preparation 20

Quellen und Nachweise

ORD-Eintrag
ord-0dce3e1866bb4bc78492428e2b755f2e
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183293B2

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