Dichloromethane → 3-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chloride

HRID 351036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351036
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19](O)=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1.[Cl:23]CCl>CN(C)C=O>[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][C:19]([Cl:23])=[O:20])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 670195353-(3-p-Tolylsulfamoyl-phenyl)-acrylic acid

Produkt 1

HCID 739893963-(3-p-Tolylsulfamoyl-phenyl)-acryloyl chlorideAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a suspension of 3-(3-p-tolylsulfamoyl-phenyl)-acrylic acid (5d) (0.75 g, 2.36 mmol) in dichloromethane (10.0 ml) oxalyl chloride (0.62 ml, 7.08 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.79 g).

Aufarbeitung

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0946ea9982c24e758df76491c41655f6
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183298B2

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